Difference between revisions of "Glycogen phosphorylase"
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An alternative rate equation without considering the allosteric regulation is given as <ref name="Lambeth_2002> Lambeth M.J. & Kushmerick M.J. (2002). ''A computational model for glycogenolysis in skeletal muscle''. Ann Biomed Eng 30, 808–827</ref> | An alternative rate equation without considering the allosteric regulation is given as <ref name="Lambeth_2002> Lambeth M.J. & Kushmerick M.J. (2002). ''A computational model for glycogenolysis in skeletal muscle''. Ann Biomed Eng 30, 808–827</ref> | ||
− | <center><math> \frac{V_{maxf} \frac{Glycogen_{n+1} \times Pi}{K_{iGlyf} \times K_{Pi}} -\frac{V_{maxf} \times K_{Glyb} \times K_{iGlc1P}}{K_{iGlyf} \times K_{Pi} \times Keq} \frac{Glycogen_n \times Glc1P}{K_{Glyb} \times K_{iGlc1P}} }{1} </math></center> | + | <center><math> \frac{V_{maxf} \frac{Glycogen_{n+1} \times Pi}{K_{iGlyf} \times K_{Pi}} -\frac{V_{maxf} \times K_{Glyb} \times K_{iGlc1P}}{K_{iGlyf} \times K_{Pi} \times Keq} \times \frac{Glycogen_n \times Glc1P}{K_{Glyb} \times K_{iGlc1P}} }{1 + \frac{Glycogen_{n+1}}{K_{iGlyf}} + \frac{Pi}{K_{iPi}} + \frac{Glycogen_n}{K_{iGlyb}} + \frac{Glc1P}{K_{iGlc1P}} \frac{Glycogen_{n+1} \times Pi}{K_{Glyf} \times K_{iPi}} + \frac{Glycogen_n \times Glc1P}{K_{Glyb} \times K_{iGlc1P}} } </math></center> |
==Parameter values== | ==Parameter values== |
Revision as of 11:51, 1 April 2014
Glycogen phosphorylase (GP) is a dimeric enzyme that catalyses the reaction in which the terminal glucose residue from a glycogen chain is phosphorylated and cleaved from the chain, releasing it as Glc1P.
Chemical equation
Rate equation
MWC model was used to formualte the rate law. [1]
An alternative rate equation without considering the allosteric regulation is given as [2]
Parameter values
Parameter | Value | Units | Organism | Remarks |
---|---|---|---|---|
2 | Dimensionless | Recombinant, human muscle | ||
50 | ||||
2.08 | mM | |||
4.32 | mM | |||
41.53 | mM | |||
0.67 | mM | |||
82.02 | mM | |||
27.92 | mM | |||
mM | ||||
0.53 | mM | |||
3.9 | mM | |||
7.42 | mM | |||
0.56 | mM | |||
0.27 | mM | |||
5.93 | Dimensionless | |||
34741 | Dimensionless |
The parameter for the alternative equation are
Parameter | Value | Units | Organism | Remarks |
---|---|---|---|---|
50 | Rabbit | |||
Failed to parse (Cannot store math image on filesystem.): Ka | 4 | mM | ||
Failed to parse (Cannot store math image on filesystem.): Kb | 1.7 | mM | ||
Failed to parse (Cannot store math image on filesystem.): Kp | 2.7 | mM | ||
Failed to parse (Cannot store math image on filesystem.): Kq | 0.15 | mM | ||
Failed to parse (Cannot store math image on filesystem.): Ki_1 | 2 | mM | ||
Failed to parse (Cannot store math image on filesystem.): Ki_2 | 4.7 | mM | ||
Failed to parse (Cannot store math image on filesystem.): Ki_3 | 10.1 | mM | ||
0.42 | mM |