Difference between revisions of "Monocarboxylate (Lactate) transporter"
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|2.5 <ref name="manning_2000">Manning Fox JE ''et. al.'' (2000). ''Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle''. J Physiol 529(Pt2):285-293</ref> | |2.5 <ref name="manning_2000">Manning Fox JE ''et. al.'' (2000). ''Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle''. J Physiol 529(Pt2):285-293</ref> | ||
| <math>\text{mM min}^{-1}</math> | | <math>\text{mM min}^{-1}</math> | ||
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|<math>Km_{Lactate_{in}}</math> | |<math>Km_{Lactate_{in}}</math> | ||
− | |4.5 <ref name=" | + | |4.5 <ref name="jackson_1996">Jackson VN, Halestrap AP (1996) The kinetics, substrate, and inhibitor specificity of the monocarboxylate (lactate) transporter of rat liver cells determined using the fluorescent intracellular pH indicator, 2’,7’-bis(carboxyethyl)-5(6)-carboxyfluorescein. J Biol Chem 271:861–868 </ref> |
|mM | |mM | ||
|Human tumor cells | |Human tumor cells | ||
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+ | |<math>V_{mr}</math> | ||
+ | |2.4 <ref name="jackson_1996"></ref> | ||
+ | | <math>\text{mM min}^{-1}</math> | ||
+ | |Human tumor cells | ||
+ | | | ||
+ | |- | ||
+ | |<math>Km_{Lactate_{out}}</math> | ||
+ | |4.54 <ref name="manning_2000"></ref> | ||
+ | |mM | ||
+ | |Human tumor cells | ||
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==References== | ==References== | ||
<references/> | <references/> |
Revision as of 16:26, 26 March 2014
Monocarboxylate transporters,[1] or MCTs, constitute a family of proton-linked plasma membrane transporters that carry molecules having one carboxylate group (monocarboxylates), such as lactate and pyruvate.
Chemical equation
Rate equation
Reversible Michaelis-Menten rate law is used
Parameter values
Parameter | Value | Units | Organism | Remarks |
---|---|---|---|---|
2.5 [2] | Human tumor cells | |||
4.5 [3] | mM | Human tumor cells | ||
2.4 [3] | Human tumor cells | |||
4.54 [2] | mM | Human tumor cells |
References
- ↑ Halestrap AP, Meredith D (2004). The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch. 447 (5): 619–28 (doi)
- ↑ 2.0 2.1 Manning Fox JE et. al. (2000). Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. J Physiol 529(Pt2):285-293
- ↑ 3.0 3.1 Jackson VN, Halestrap AP (1996) The kinetics, substrate, and inhibitor specificity of the monocarboxylate (lactate) transporter of rat liver cells determined using the fluorescent intracellular pH indicator, 2’,7’-bis(carboxyethyl)-5(6)-carboxyfluorescein. J Biol Chem 271:861–868