Difference between revisions of "Transformation of PGH2 to PGI2"

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(Parameters)
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==Chemical equation==
 
==Chemical equation==
  
<center><math> FA \rightleftharpoons AA </math></center>
+
<center><math> PGH2 \rightleftharpoons PGI2 </math></center>
  
 
== Rate equation ==
 
== Rate equation ==
  
 +
[[File:R05.PNG|center|500px]]
  
 
== Parameters ==
 
== Parameters ==

Revision as of 15:16, 25 September 2017

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PGH2 is metabolised into the prostacyclin PGI2, by PGIS. This species has been associated with influencing the permeability of vascular compartment (Murata, Ushikubi et al. 1997). Similarly to the TX species, prostacyclins are only found in low concentration and are associated with infiltrating cells from the vascular compartment (Sugimoto, Arai et al. 2006).

Reaction

R5 PGH2 - PGI2.jpg

Chemical equation

 PGH2 \rightleftharpoons PGI2

Rate equation

R05.PNG

Parameters

Michaelis-Menten Constants
Value Units Species Notes Reference
1.33E-02 ± 1.40E-03  mM Human Expression Vector: Bovine Endothelial and Aorta Cells

Enzyme: Human PGIS pH:7.4 Temperature: 23

[1]
9.00E-03 ± 5.00E-03  mM Bovine Expression Vector: Bovine Endothelial and Aorta Cells

Enzyme: Bovine PGIS pH:7.4 Temperature: 24

[2]
Enzyme Turnover Numbers
Value Units Species Notes Reference
147 ± 45 per minute Cattle Expression Vector: E. Coli

Enzyme: Bovine PGIS pH:7.4 Temperature: 24

[2]
PGIS Abundance
Value Units Species Notes Reference
412  ppm Human Expression Vector: Urinary bladder

Enzyme: PGIS pH: 7.5 Temperature: 37 °C

[3]
206  ppm Human Expression Vector: Lung

Enzyme: PGIS pH: 7.5 Temperature: 37 °C

[3]
60.1  ppm Human Expression Vector: Esophagus

Enzyme: PGIS pH: 7.5 Temperature: 37 °C

[3]
9.93  ppm Human Expression Vector: Oral Cavity

Enzyme: PGIS pH: 7.5 Temperature: 37 °C

[4]
Gibbs Free Energy Change
Value Units Species Notes Reference
0.04 kcal/mol Not stated Estimated

Enzyme: Transacylase Substrate: Product: pH: 7.3 ionic strength: 0.25

[5]

References

Related Reactions