Difference between revisions of "Transformation of LTA4 to LTB4"
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− | |+ style="text-align: left;" | | + | |+ style="text-align: left;" | LTA4H Abundance |
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! Value | ! Value | ||
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! Reference | ! Reference | ||
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− | | | + | |714 |
− | | | + | |<math> ppm </math> |
− | |Human | + | |Human |
− | |Expression Vector: | + | |Expression Vector: Lung |
− | Enzyme: | + | Enzyme: LTA4H |
− | pH: | + | pH: 7.5 |
− | Temperature: | + | Temperature: 37 °C |
− | + | |<ref name="Kim2014"> [http://www.nature.com/nature/journal/v509/n7502/pdf/nature13302.pdf M. Kim ''A draft map of the human proteome'' Nature, 2014 509, 575–581]</ref> | |
− | |<ref name=" | + | |- |
+ | |489 | ||
+ | |<math> ppm </math> | ||
+ | |Human | ||
+ | |Expression Vector: Skin | ||
+ | Enzyme: LTA4H | ||
+ | pH: 7.5 | ||
+ | Temperature: 37 °C | ||
+ | |<ref name="Wilhelm2014"> [http://www.nature.com/nature/journal/v509/n7502/pdf/nature13319.pdf M. Wilhelm ''Mass-spectrometry-based draft of the human proteome'' Nature, 2014 509, 582–587]</ref> | ||
|- | |- | ||
− | | | + | |410 |
− | | | + | |<math> ppm </math> |
− | |Human | + | |Human |
− | |Expression Vector: | + | |Expression Vector: Oral Cavity |
− | Enzyme: | + | Enzyme: LTA4H |
− | pH: 7. | + | pH: 7.5 |
Temperature: 37 °C | Temperature: 37 °C | ||
− | |<ref name=" | + | |<ref name="Wilhelm2014"> [http://www.nature.com/nature/journal/v509/n7502/pdf/nature13319.pdf M. Wilhelm ''Mass-spectrometry-based draft of the human proteome'' Nature, 2014 509, 582–587]</ref> |
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Revision as of 12:58, 12 August 2016
Contents
Reaction
Chemical equation
Rate equation
Parameters
Value | Units | Species | Notes | Reference |
---|---|---|---|---|
5.80E-03 | mM | Human | Expression Vector: E. Coli
Enzyme: Wild Type Leukotriene A4 hydrolase: pH:8 Temperature: 20 (Room Temperature) |
[1] |
2.70E-03 | mM | Frog | Expression Vector: oocytes
Enzyme: leukotriene A4 hydrolase pH:8 Temperature: 20 (Room Temperature) |
[2] |
2.20E-02 | mM | Human | Expression Vector: Leukocytes
Enzyme: Leukotriene A4 Hydrolase pH: 8 Temperature:2°C |
[3] |
2.30E-03 | Expression Vector: Leukocytes
Enzyme: Leukotriene A4 Hydrolase pH: 8 Temperature:37°C |
Value | Units | Species | Notes | Reference |
---|---|---|---|---|
12.6 - 28.2 | per minute | Human | Expression Vector: E. Coli.
Enzyme: Leukotriene A4 Hydrolase pH: 7.4 Temperature: 37 °C |
[4] |
51 | per minute | Human | Expression Vector: E. Coli
Enzyme: Wild Type Leukotriene A4 hydrolase: pH:8 Temperature: 20 (Room Temperature) |
[1] |
90 | per minute | Frog | Expression Vector: oocytes
Enzyme: leukotriene A4 hydrolase pH:8 Temperature: 20 (Room Temperature) |
[2] |
125 | per minute | Human | Expression Vector: Leukocytes
Enzyme: Leukotriene A4 Hydrolase pH: 8 Temperature:37°C |
[3] |
Value | Units | Species | Notes | Reference |
---|---|---|---|---|
714 | Human | Expression Vector: Lung
Enzyme: LTA4H pH: 7.5 Temperature: 37 °C |
[5] | |
489 | Human | Expression Vector: Skin
Enzyme: LTA4H pH: 7.5 Temperature: 37 °C |
[6] | |
410 | Human | Expression Vector: Oral Cavity
Enzyme: LTA4H pH: 7.5 Temperature: 37 °C |
[6] |
References
- ↑ 1.0 1.1 [www.ncbi.nlm.nih.gov/pubmed/8650196 Mueller M. , "Leukotriene A4 hydrolase: protection from mechanism-based inactivation by mutation of tyrosine-378. Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5931-5.]
- ↑ 2.0 2.1 [www.ncbi.nlm.nih.gov/pubmed/9744798 Stromberg F. , "Purification and characterization of leukotriene A4 hydrolase from Xenopus laevis oocytes. FEBS Lett. 1998 Aug 21;433(3):219-22.]
- ↑ 3.0 3.1 [www.ncbi.nlm.nih.gov/pubmed/6490615 Radmark O. , "Leukotriene A4 hydrolase in human leukocytes. Purification and properties J Biol Chem. 1984 Oct 25;259(20):12339-45.]
- ↑ [www.ncbi.nlm.nih.gov/pubmed/11675384 Rudberg P. , "Leukotriene A4 Hydrolase/Aminopeptidase The Journal of Biological Chemistry, 277, 1398-1404.]
- ↑ M. Kim A draft map of the human proteome Nature, 2014 509, 575–581
- ↑ 6.0 6.1 M. Wilhelm Mass-spectrometry-based draft of the human proteome Nature, 2014 509, 582–587