Difference between revisions of "Pentose Phosphate Pathway"
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The '''pentose phosphate pathway''' is a process used to generate [http://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide NADPH] and [http://en.wikipedia.org/wiki/Pentose pentose]s (5-[http://en.wikipedia.org/wiki/Carbon carbon] [http://en.wikipedia.org/wiki/Sugar sugar]s). This pathway is composed of two distinct phases. The first is the [http://en.wikipedia.org/wiki/Oxidative oxidative] phase, in which NADPH is generated, and the second is the non-oxidative synthesis of 5-carbon sugars. This pathway is an alternative to glycolysis. Although it does involve oxidation of glucose, its primary role is anabolic rather than catabolic. | The '''pentose phosphate pathway''' is a process used to generate [http://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide NADPH] and [http://en.wikipedia.org/wiki/Pentose pentose]s (5-[http://en.wikipedia.org/wiki/Carbon carbon] [http://en.wikipedia.org/wiki/Sugar sugar]s). This pathway is composed of two distinct phases. The first is the [http://en.wikipedia.org/wiki/Oxidative oxidative] phase, in which NADPH is generated, and the second is the non-oxidative synthesis of 5-carbon sugars. This pathway is an alternative to glycolysis. Although it does involve oxidation of glucose, its primary role is anabolic rather than catabolic. | ||
| − | == | + | ==Description of the model== |
| − | <center><math> | + | This diagram describes the set of reactions that take place in the pentose phosphate pathway. The dotted line means there is inhibition of an enzyme. |
| + | <imagemap> | ||
| + | File:Pentose_phosphate_scheme.png|frameless|center|600px | ||
| + | |||
| + | circle 484 89 15 [[Glucose-6-Phosphate Dehydrogenase]] | ||
| + | circle 383 87 15 [[6-phosphogluconolactonase]] | ||
| + | circle 278 88 15 [[6-phosphogluconate dehydrogenase]] | ||
| + | circle 155 120 15 [[Ribulose 5-phosphate 3-epimerase]] | ||
| + | circle 228 123 15 [[Ribose 5-phosphate isomerase]] | ||
| + | circle 186 192 15 [[Transkelotase]] | ||
| + | circle 88 339 15 [[Transkelotase]] | ||
| + | circle 183 267 15 [[Transaldolase]] | ||
| + | |||
| + | desc bottom-right | ||
| + | </imagemap> | ||
| + | |||
| + | ==Reactions== | ||
| + | *[[Glucose-6-Phosphate Dehydrogenase]] | ||
| + | *[[6-phosphogluconolactonase]] | ||
| + | *[[6-phosphogluconate dehydrogenase]] | ||
| + | *[[Ribulose 5-phosphate 3-epimerase]] | ||
| + | *[[Ribose 5-phosphate isomerase]] | ||
| + | *[[Transkelotase]] | ||
| + | *[[Transaldolase]] | ||
| + | |||
| + | ==Alternative== | ||
| + | *Constant flux can be used | ||
| + | |||
| + | {|class="wikitable" | ||
| + | ! Parameter | ||
| + | ! Value | ||
| + | ! Organism | ||
| + | ! Remarks | ||
| + | |- | ||
| + | |<math>V</math> | ||
| + | |<math>9.5^{-05}</math> | ||
| + | | | ||
| + | |Constant Flux | ||
| + | |} | ||
| + | |||
| + | ==Parameters with uncertainty== | ||
| + | |||
| + | '''Alternative''' | ||
| + | {|class="wikitable" | ||
| + | ! Parameter | ||
| + | ! Value | ||
| + | ! Organism | ||
| + | ! Remarks | ||
| + | |- | ||
| + | |<math>V</math> | ||
| + | |<math>9.5^{-05}\pm 3.5^{-05}</math> | ||
| + | | | ||
| + | |Constant Flux | ||
| + | |} | ||
| + | |||
| + | ==References== | ||
| + | <references/> | ||
Latest revision as of 11:49, 3 July 2014
The pentose phosphate pathway is a process used to generate NADPH and pentoses (5-carbon sugars). This pathway is composed of two distinct phases. The first is the oxidative phase, in which NADPH is generated, and the second is the non-oxidative synthesis of 5-carbon sugars. This pathway is an alternative to glycolysis. Although it does involve oxidation of glucose, its primary role is anabolic rather than catabolic.
Contents
Description of the model
This diagram describes the set of reactions that take place in the pentose phosphate pathway. The dotted line means there is inhibition of an enzyme.
Reactions
- Glucose-6-Phosphate Dehydrogenase
- 6-phosphogluconolactonase
- 6-phosphogluconate dehydrogenase
- Ribulose 5-phosphate 3-epimerase
- Ribose 5-phosphate isomerase
- Transkelotase
- Transaldolase
Alternative
- Constant flux can be used
| Parameter | Value | Organism | Remarks |
|---|---|---|---|
|
|
Constant Flux |
Parameters with uncertainty
Alternative
| Parameter | Value | Organism | Remarks |
|---|---|---|---|
|
|
|
Constant Flux |
