Difference between revisions of "Pentose Phosphate Pathway"
| Line 2: | Line 2: | ||
The '''pentose phosphate pathway''' is a process used to generate [http://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide NADPH] and [http://en.wikipedia.org/wiki/Pentose pentose]s (5-[http://en.wikipedia.org/wiki/Carbon carbon] [http://en.wikipedia.org/wiki/Sugar sugar]s). This pathway is composed of two distinct phases. The first is the [http://en.wikipedia.org/wiki/Oxidative oxidative] phase, in which NADPH is generated, and the second is the non-oxidative synthesis of 5-carbon sugars. This pathway is an alternative to glycolysis. Although it does involve oxidation of glucose, its primary role is anabolic rather than catabolic. | The '''pentose phosphate pathway''' is a process used to generate [http://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide NADPH] and [http://en.wikipedia.org/wiki/Pentose pentose]s (5-[http://en.wikipedia.org/wiki/Carbon carbon] [http://en.wikipedia.org/wiki/Sugar sugar]s). This pathway is composed of two distinct phases. The first is the [http://en.wikipedia.org/wiki/Oxidative oxidative] phase, in which NADPH is generated, and the second is the non-oxidative synthesis of 5-carbon sugars. This pathway is an alternative to glycolysis. Although it does involve oxidation of glucose, its primary role is anabolic rather than catabolic. | ||
| − | == | + | ==Description of the model== |
| − | + | This diagram describes the set of reactions that take place in the pentose phosphate pathway. The dotted line means there is inhibition of an enzyme. | |
| − | + | ==Reactions== | |
| − | == | + | *[[Glucose-6-Phosphate Dehydrogenase]] |
| − | + | *[[6-phosphogluconolactonase]] | |
| − | + | *[[6-phosphogluconate dehydrogenase]] | |
| + | *[[Ribulose 5-phosphate 3-epimerase]] | ||
| + | *[[Ribose 5-phosphate isomerase]] | ||
| + | *[[Transkelotase]] | ||
| + | *[[Transaldolase]] | ||
==Parameter values== | ==Parameter values== | ||
{|class="wikitable" | {|class="wikitable" | ||
Revision as of 11:40, 2 July 2014
The pentose phosphate pathway is a process used to generate NADPH and pentoses (5-carbon sugars). This pathway is composed of two distinct phases. The first is the oxidative phase, in which NADPH is generated, and the second is the non-oxidative synthesis of 5-carbon sugars. This pathway is an alternative to glycolysis. Although it does involve oxidation of glucose, its primary role is anabolic rather than catabolic.
Contents
Description of the model
This diagram describes the set of reactions that take place in the pentose phosphate pathway. The dotted line means there is inhibition of an enzyme.
Reactions
- Glucose-6-Phosphate Dehydrogenase
- 6-phosphogluconolactonase
- 6-phosphogluconate dehydrogenase
- Ribulose 5-phosphate 3-epimerase
- Ribose 5-phosphate isomerase
- Transkelotase
- Transaldolase
Parameter values
| Parameter | Value | Organism | Remarks |
|---|---|---|---|
|
 [1]
|
HeLa cell line | Constant flux |
Parameters with uncertainty
| Parameter | Value | Organism | Remarks |
|---|---|---|---|
|
|
Failed to parse (Cannot store math image on filesystem.): 9.5 \times 10^{-5} \pm 3.0 \times 10^{-5} [1] | HeLa cell line | Constant flux |
