Difference between revisions of "Pentose Phosphate Pathway"

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The '''pentose phosphate pathway''' is a process used to generate [http://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide NADPH] and [http://en.wikipedia.org/wiki/Pentose pentose]s (5-[http://en.wikipedia.org/wiki/Carbon carbon] [http://en.wikipedia.org/wiki/Sugar sugar]s). This pathway is composed of two distinct phases. The first is the [http://en.wikipedia.org/wiki/Oxidative oxidative] phase, in which NADPH is generated, and the second is the non-oxidative synthesis of 5-carbon sugars. This pathway is an alternative to glycolysis. Although it does involve oxidation of glucose, its primary role is anabolic rather than catabolic.
 
The '''pentose phosphate pathway''' is a process used to generate [http://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide NADPH] and [http://en.wikipedia.org/wiki/Pentose pentose]s (5-[http://en.wikipedia.org/wiki/Carbon carbon] [http://en.wikipedia.org/wiki/Sugar sugar]s). This pathway is composed of two distinct phases. The first is the [http://en.wikipedia.org/wiki/Oxidative oxidative] phase, in which NADPH is generated, and the second is the non-oxidative synthesis of 5-carbon sugars. This pathway is an alternative to glycolysis. Although it does involve oxidation of glucose, its primary role is anabolic rather than catabolic.
  

Revision as of 16:48, 1 May 2014


The pentose phosphate pathway is a process used to generate NADPH and pentoses (5-carbon sugars). This pathway is composed of two distinct phases. The first is the oxidative phase, in which NADPH is generated, and the second is the non-oxidative synthesis of 5-carbon sugars. This pathway is an alternative to glycolysis. Although it does involve oxidation of glucose, its primary role is anabolic rather than catabolic.

Chemical equation

Glc6P \rightarrow 6PG

Rate equation

Constant flux is considered for this pathway in this model where the flux vlaue is  v = 9.5 \times 10^{-5}

Parameter values

Parameter Value Organism Remarks
V 9.5 \times 10^{-5} [1] HeLa cell line Constant flux

References

  1. Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S et al (2011) Modeling cancer glycolysis. Biochim Biophys Acta 1807:755–767 (doi)